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Brain metastasis and breast cancer

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When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Chemotherapy drugs targeting breast cancer cells in the brain aren't effective, because they can't cross the blood-brain-barrier. But a new combination therapy targeting breast cancer tumors in the brain dramatically decreased tumor size and increased survival in a study with mice, reports a new Northwestern Medicine study.
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Secondary breast cancer in the brain

Brain metastasis and breast cancer
Brain metastasis and breast cancer
Brain metastasis and breast cancer
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Breast cancer brain metastases: biology and new clinical perspectives

At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns.
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Mapping out the treatment of breast cancer-related brain metastases

September 18, Breast cancer patients whose disease has spread to their brains fare better if their metastases are picked up before they begin to cause symptoms, according to a study presented at the 12th European Breast Cancer Conference. Breast cancer that spreads to the brain is becoming more common and it is one reason why the disease becomes untreatable. However, asymptomatic brain metastases can be identified with an MRI scan and the new research suggests that doing so could mean less aggressive treatment and a longer survival time. Patients with other forms of cancer that tend to spread to the brain, such as lung cancer , are already given a brain scan when they are first diagnosed.
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Aggressive metastatic breast cancer cells growing in the brains of fish embryos. The tumors are resistant to anti-HER2 therapy SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. HER2 protein is a strong driver of tumor growth. HER2 targeting therapies, such as Herceptin, are widely used in clinical care and it plays an important role in the treatment of HER2-positive cancers.
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